Pyrazine, 5-chloro-2,3-diphenyl-

Pyrazine, 5-chloro-2,3-diphenyl- - Names and Identifiers

Name	5-Chloro-2,3-diphenylpyrazine
Synonyms	Selexipag Impurity 31 5-Chloro-2,3-diphenylpyrazine 5-chloro-2,3-diphenylpyrazine 2-Chloro-5,6-diphenylpyrazine Pyrazine, 5-chloro-2,3-diphenyl- 5-Chloro-2,3-diphenylpyrazine fandachem chloro-2,3-diphenylpyrazine (Selexipag Intermediate)
CAS	41270-66-0
EINECS	813-797-2

Pyrazine, 5-chloro-2,3-diphenyl- - Physico-chemical Properties

Molecular Formula	C16H11ClN2
Molar Mass	266.72
Density	1?+-.0.06 g/cm3(Predicted)
Melting Point	126-128℃ (methanol )
Boling Point	145°C/0.001mmHg(lit.)
pKa	-2.16±0.10(Predicted)
Storage Condition	-20℃

Pyrazine, 5-chloro-2,3-diphenyl- - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	3.749 ml	18.746 ml	37.492 ml
5 mM	0.75 ml	3.749 ml	7.498 ml
10 mM	0.375 ml	1.875 ml	3.749 ml
5 mM	0.075 ml	0.375 ml	0.75 ml

Last Update：2024-01-02 23:10:35

Pyrazine, 5-chloro-2,3-diphenyl- - Introduction

5-Chloro-2,3-diphenylpyrazine is an organic compound with the molecular formula C18H13ClN, and the structure contains a chlorine atom and two benzene rings. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 5-Chloro-2,3-diphenylpyrazine is a colorless crystal or a white solid.
-Solubility: It has good solubility in organic solvents, such as ether, xylene, etc.
-Melting point: Its melting point is about 180-182 degrees Celsius.
-Stability: Under regular temperature and pressure, the compound is stable, but it needs to avoid light and oxidizing agents.

Use:
5-choro-2, 3-diphenylpyrazine is a compound widely used in organic synthesis and medicine. It has good spectral properties and oxidation resistance, and is commonly used in dyes, luminescent materials and organic optoelectronic devices.
In addition, it can also be used as a structurally active compound for drug synthesis or as a drug precursor, with certain biological activity.

Preparation Method:
5-Chloro-2,3-diphenylpyrazine can be synthesized by a variety of methods. A common method is the reaction of 2,3-diphenylpyrazine with thionyl chloride to give the desired product. The specific operating conditions and steps need to be determined according to the specific conditions and requirements of the laboratory.

Safety Information:
When using and handling 5-choro-2, 3-diphenylpyrazine, the following safety measures should be followed:
-Avoid contact with skin and eyes and wear appropriate personal protective equipment such as gloves, goggles and lab coats if necessary.
-A well-ventilated laboratory environment should be maintained during operation.
-Avoid inhaling the vapor of its dust or dissolved liquid to avoid damage to the respiratory system.
-Store in a cool, dry place away from open flames and oxidizing agents.
-When no longer required, its waste should be safely disposed of, complying with local regulations.

Last Update：2024-04-09 01:59:57